Department Of Surgery
Research from the Dept. of Surgery has been published in numerous peer reviewed journals. Some of research highlights can be viewed below. We also endeavour to encourage the future generation of researchers by participating in school talks across the country.
Prof. Jacintha O’Sullivan
About: Prof. Jacintha O’Sullivan is a Professor in Translational Oncology, based at the Trinity Translational Medicine Institute (TTMI), St. James’s Hospital.
Read Her Latest Published Research Below
Prof. John Reynolds
About: Professor Reynolds is Professor of Clinical Surgery at the St. James’s Hospital and Trinity College Dublin.
Read His Latest Published Research Below
- Extratumoral PD-1 blockade does not perpetuate obesity-associated inflammation in esophageal adenocarcinoma.
- Human dorsal root ganglion pulsed radiofrequency treatment modulates cerebrospinal fluid lymphocytes and neuroinflammatory markers in chronic radicular pain.
- Patient experiences of a physiotherapy-led multidisciplinary rehabilitative intervention after successful treatment for oesophago-gastric cancer.
- MicroRNA-17 is downregulated in esophageal adenocarcinoma cancer stem-like cells and promotes a radioresistant phenotype.
- HLA-DR expression in tumor epithelium is an independent prognostic indicator in esophageal adenocarcinoma.
- A Quininib Analogue and Cysteinyl Leukotriene Receptor Antagonist Inhibits Vascular Endothelial Growth Factor (VEGF)-independent Angiogenesis and Exerts an Additive Antiangiogenic Response with Bevacizumab.
- Advances in Precision Medicine: Tailoring Individualised Therapies.
- Effects of a multimodal rehabilitation programme on inflammation and oxidative stress in oesophageal cancer survivors: the ReStOre feasibility study.
- Emerging Concepts linking obesity with the hallmarks of cancer.
- Impact of visceral obesity and metabolic syndrome on the postoperative immune, inflammatory, and endocrine response following surgery for esophageal adenocarcinoma.
- Enrichment of Inflammatory IL-17 and TNF-α Secreting CD4(+) T Cells within Colorectal Tumors despite the Presence of Elevated CD39(+) T Regulatory Cells and Increased Expression of the Immune Checkpoint Molecule, PD-1.
- Obesity-associated cancer: an immunological perspective.
- Big Data-Led Cancer Research, Application, and Insights.
- Fractionated radiation exposure amplifies the radioresistant nature of prostate cancer cells.
- Low miR-187 expression promotes resistance to chemoradiation therapy in vitro and correlates with treatment failure in patients with esophageal adenocarcinoma.
- Anti-cancer effects of baicalein in non-small cell lung cancer in-vitro and in-vivo
- Parallel Profiles of Inflammatory and Effector Memory T Cells in Visceral Fat and Liver of Obesity-Associated Cancer Patients
- Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer.
- Preclinical validation of Quininib as a novel anti-angiogenic drug for colorectal cancer.
- Changes in mitochondrial stability during the progression of the Barrett’s esophagus disease sequence.
- Current targeted therapies in the treatment of advanced colorectal cancer: a review.
- Visceral obesity stimulates anaphase bridge formation and spinde assembly checkpoint dysregulation in radioresistant oesophageal adenocarcinoma.
- Dysregulated Bioenergetics: A key regulator of joint inflammation.
- Protein Kinase C Beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival.
- Examining the connectivity between different cellular processes in the Barrett tissue microenvironment.
- Impact of the inflammatory microenvironment on T-cell phenotype in the progression from reflux oesophagitis to Barrett oesophagus and oesophageal adenocarcinoma.
- CCR1 antagonism attenuates T cell trafficking to omentum and liver in obesity-associated cancer.
- The microenvironment of visceral adipose tissue and liver alter natural killer cell viability and function.